Cholesteryl hemisuccinate
Cat. No.：YN270671
| 产品名称: | Cholesteryl hemisuccinate |
| CAS No.: | 1510-21-0 |
| Chemical Name: | (3β)-cholest-5-en-3-ol 3-(hydrogen butanedioate) |
| Synonyms: | 胆固醇琥珀酸单酯; Cholesterol hydrogen succinate |
| 分子量: | 486.7263 |
| 分子式: | C31H50O4 |
| SMILES: | C[C@]12C(C[C@@H](OC(CCC(O)=O)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@@H](CCCC(C)C)C)[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cholesteryl hemisuccinate 是一种具有保肝和抗癌活性的物质。Cholesteryl hemisuccinate 抑制对乙酰氨基酚 (AAP, HY-66005) 的肝毒性，并防止 AAP 诱导的肝细胞凋亡 (apoptosis) 和坏死 (necrosis)。Cholesteryl hemisuccinate 抑制 DNA 聚合酶 (DNA polymerase) 和 DNA 拓扑异构酶 (DNAtopoisomerase)，从而抑制 DNA 复制和修复以及细胞分裂。因此，胆固醇半 |
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Fariss, M.W., Fortuna, M.B., Everett, C.K., et al.The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compoundsCancer Res.54(13),3346-3351(1994)
Ding, W.X., Qi, X.R., Li, P., et al.Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-dInt. J. Pharm.300(1-2),38-47(2005)
Simões, S., Moreira, J.N., Fonseca, C., et al.On the formulation of pH-sensitive liposomes with long circulation timesAdv. Drug Deliv. Rev.56(7),947-965(2004)
Allen, S.J., Ribeiro, S., Horuk, R., et al.Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1Protein Expr. Purif.66(1),73-81(2009)
Grodecka, M., Bertrand, O., Karolak, E., et al.One-step immunopurification and lectinochemical characterization of the Duffy atypical chemokine receptor from human erythrocytesGlycoconj. J.29(2-3),93-105(2012)
