DBIBB
Cat. No.：YN270675
CAS No. ：1569309-92-7
| 产品名称: | DBIBB |
| CAS No.: | 1569309-92-7 |
| Chemical Name: | 2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]-benzoic acid |
| Synonyms: | |
| 分子量: | 452.5 |
| 分子式: | C23H20N2O6S |
| SMILES: | O=C(C1=C2C(C=CC=C23)=CC=C1)N(CCCCNS(C4=C(C(O)=O)C=CC=C4)(=O)=O)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DBIBB 是溶血磷脂酸 (LPA2) 的 2 型 G 蛋白偶联受体的特异性非脂质激动剂。DBIBB 可减轻胃肠道辐射综合征，增加肠隐窝存活率和肠细胞增殖，并减少细胞凋亡 (apoptosis)。DBIBB 是一种能够缓解高剂量 γ 射线对造血和胃肠系统引起的急性放射综合征的候选活性分子。 |
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Lin, F.T., Lai, Y.J., Makarova, N., et al.The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survivalJ. Biol. Chem.282(52),37759-37769(2007)
Patil, R., Szabó, E., Fells, J.I., et al.Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonistChem. Biol.22,206-216(2015)
