Erastin2
Cat. No.：YN270679
CAS No. ：1695533-44-8
| 产品名称: | Erastin2 |
| CAS No.: | 1695533-44-8 |
| Chemical Name: | 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone |
| Synonyms: | |
| 分子量: | 623.14036 |
| 分子式: | C36H35ClN4O4 |
| SMILES: | O=C1N(C2=CC(C3=CC=CC=C3)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Erastin2 是一种铁坏死的诱导剂，是 xc (-) 胱氨酸/谷氨酸转运体系统的有效的选择性抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cao, J.Y., Poddar, A., Magtanong, L., et al.A genome-wide haploid genetic screen identifies regulators of glutathione abundance and ferroptosis sensitivityCell Rep.26(6),1544-1556(2019)
Dixon, S.J., Patel, D.N., Welsch, M., et al.Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosisElife3,e02523(2014)
Magtanong, L., Ko, P.-J., To, M., et al.Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell stateCell Chem. Biol.26(3),420-432(2019)
