MC1742
Cat. No.：YN270681
CAS No. ：1776116-74-5
| 产品名称: | MC1742 |
| CAS No.: | 1776116-74-5 |
| Chemical Name: | 5-[(4-[1,1′-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-pentanamide |
| Synonyms: | MC-1742; MC 1742; MC1742. |
| 分子量: | 395.47586 |
| 分子式: | C21H21N3O3S |
| SMILES: | O=C1N=C(SCCCCC(NO)=O)NC(C(C=C2)=CC=C2C3=CC=CC=C3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MC1742 是一种有效的HDAC抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8、HDAC10 和HDAC11的IC50分别为 0.1 μM、0.11 μM、0.02 μM、0.007 μM、0.61 μM、0.04 μM 和 0.1 μM。MC1742 可以增加乙酰 - H3 和乙酰微管蛋白的水平，抑制癌症干细胞 (CSC) 的生长。MC1742 可诱导肉瘤干细胞生长停滞、凋亡 (apoptosis) 和分化。 |
| IC50和靶点: | [{name:"HDAC1:0.1 μM (IC50)"},{name: "HDAC2:0.11 μM (IC50)"},{name: "HDAC3:0.02 μM (IC50)"},{name: "HDAC6:0.007 μM (IC50)"},{name: "HDAC8:0.61 μM (IC50)"},{name: "HDAC10:0.04 μM (IC50)"},{name: "HDAC11:0.1 μM (IC50)"}] |
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Di Pompo, G., Salerno, M., Rotili, D., et al.Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cellsJ. Med. Chem.58(9),4073-4079(2015)
Heffern, E.F.W., Ramani, R., Marshall, G., et al.Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latencyJ. Virus Erad.5(2),84-91(2019)
