Ac-YVAD-cmk
Cat. No.：YN270682
| 产品名称: | Ac-YVAD-cmk |
| CAS No.: | 178603-78-6 |
| Chemical Name: | N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxo-propyl]-L-alaninamide |
| Synonyms: | Caspase-1 Inhibitor II |
| 分子量: | 541 |
| 分子式: | C24H33ClN4O8 |
| SMILES: | ClCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)Cc1ccc(O)cc1)C(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ac-YVAD-cmk (Caspase-1 Inhibitor II) 是一种选择性caspase-1(IL-1β转化酶，ICE) 抑制剂，具有神经保护和抗炎作用。Ac-YVAD-cmk能有效抑制 IL-1β 和IL-18的表达。Ac-YVAD-cmk 可抑制多种疾病的细胞焦亡 (pyroptosis)。 |
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Rabuffetti, M., Sciorati, C., Tarozzo, G., et al.Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokinesJ. Neurosci.20,4398-4404(2000)
