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Boc-Asp(OMe)-fluoromethyl ketone

Cat. No.:YN270688

  • CAS No. :187389-53-3

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    • 参考文献
    • 产品名称: Boc-Asp(OMe)-fluoromethyl ketone
      CAS No.: 187389-53-3
      Chemical Name: 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester
      Synonyms:Boc-Asp(OMe
      分子量:263.3
      分子式:C11H18FNO5
      SMILES:FCC([C@@H](NC(OC(C)(C)C)=O)CC(OC)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Boc-Asp(OME)-Fluoromethyl Keton 是一种广泛的caspase抑制剂,可抑制Fas介导的吞噬作用和氧化破裂抑制,但不影响IL-8的趋化活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
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    • Chauvier, D., Ankri, S., Charriaut-Marlangue, C., et al.Broad-spectrum caspase inhibitors: From myth to reality?Cell Death Differ.14(2),387-391(2007)

      Gregoli, P.A., and Bondurant, M.C.Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitorsJ. Cell Physiol.178(2),133-143(1999)

      Cowburn, A.S., White, J.F., Deighton, J., et al.z-VAD-fmk augmentation of TNFα-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen speciesBlood105(7),2970-2972(2005)

      Sheen-Chen, S.M., Hung, K.S., and Eng, H.L.Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challengeJ. Gastroenterol. Hepatol.23(8 Pt 1),1276-1279(2008)

      Wu, X., Guo, R., Chen, P., et al.TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanismAm. J. Physiol. Renal. Physiol.297(2),F316-F326(2009)

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