Eupatorin
Cat. No.：YN270709
| 产品名称: | Eupatorin |
| CAS No.: | 226929-39-1 |
| Chemical Name: | [1-[[1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinyl-methanone |
| Synonyms: | LB-42708,LB 42708 |
| 分子量: | 555.5 |
| 分子式: | C30H27BrN4O2 |
| SMILES: | O=C(C1=CN(CC2=CN=CN2CC3=CC=C(Br)C=C3)C=C1C4=CC=CC5=C4C=CC=C5)N6CCOCC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LB42708 是一种有效的、选择性的和具有口服活性的法尼基转移酶 (farnesyltransferase)抑制剂。 LB42708 抑制H-Ras、N-Ras和K-Ras4B的法尼基化，IC50分别为 0.8 nM、1.2 nM 和 2.0 nM。 |
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Appels, N.M.G.M., Beijnen, J.H., and Schellens, J.H.M.Development of farnesyl transferase inhibitors: A reviewOncologist10(8),565-578(2005)
Berndt, N., Hamilton, A.D., and Sebti, S.M.Targeting protein prenylation for cancer therapyNat. Rev. Cancer11(11),775-791(2011)
Na, H.J., Lee, S.J., Kang, Y.C., et al.Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21ras-dependent NF-κB activationJ. Immunol.173(2),1276-1283(2004)
Kim, C.K., Choi, Y.K., Ha, K.S., et al.The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathwaysMol. Pharmacol.78(1),142-150(2010)
