STM2457
Cat. No.：YN270722
| 产品名称: | STM2457 |
| CAS No.: | 2499663-01-1 |
| Chemical Name: | N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| Synonyms: | |
| 分子量: | 444.52906 |
| 分子式: | C25H28N6O2 |
| SMILES: | O=C1C=C(C(NCC2=CN3C=C(CNCC4CCCCC4)C=CC3=N2)=O)N=C5C=CC=CN15 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | STM2457 是一种首创的，高效、选择性的，具有口服活性的METTL3抑制剂，其IC50为 16.9 nM.，可用于急性白血病的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yankova, E., Blackaby, W., Albertella, M., et al.Small molecule inhibition of METTL3 as a strategy against myeloid leukaemiaNature593(7860),597-601(2021)
Xu, Q.-C., Tien, Y.-C., Shi, Y.-H., et al.METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent mannerOncogene41(11),1622-1633(2022)
