S-Trityl-L-cysteine
Cat. No.：YN270731
| 产品名称: | S-Trityl-L-cysteine |
| CAS No.: | 2799-07-7 |
| Chemical Name: | S-(triphenylmethyl)-L-cysteine |
| Synonyms: | NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine |
| 分子量: | 363.5 |
| 分子式: | C22H21NO2S |
| SMILES: | N[C@H](C(O)=O)CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | S-Trityl-L-cysteine (NSC 83265) 是一种选择性的别构驱动蛋白Eg5抑制剂，抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 具有抗肿瘤活性。 |
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Skoufias, D.A., DeBonis, S., Saoudi, Y., et al.S-Trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progressionJ. Biol. Chem.281(26),17559-17569(2006)
DeBonis, S., Skoufias, D.A., Lebeau, L., et al.In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activitiesMol. Cancer Ther.3(9),1079-1090(2004)
