Ucf-101
Cat. No.：YN270737
CAS No. ：313649-08-0
| 产品名称: | Ucf-101 |
| CAS No.: | 313649-08-0 |
| Chemical Name: | dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| Synonyms: | UCF 101;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| 分子量: | 495.5 |
| 分子式: | C27H17N3O5S |
| SMILES: | S=C(N(C1=CC=CC=C1)C(/C2=C\C3=CC=C(C4=CC=CC=C4[N+]([O-])=O)O3)=O)N(C5=CC=CC=C5)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ucf-101 是一种选择性和竞争性的促凋亡蛋白酶Omi/HtrA2抑制剂，抑制His-Omi的IC50值为 9.5 μM。Ucf-101 对各种其他丝氨酸蛋白酶的活性极低 (IC50>200 μM)。Ucf-101 在 543 nm 处具有天然的红色荧光，可用于监视其进入哺乳动物细胞的能力。Ucf-101 对 MI/R 损伤具有明显的心脏保护作用，并且还具有一定的神经保护作用。 |
| IC50和靶点: | |
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Cilenti, L., Lee, Y., Hess, S., et al.Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2J. Biol. Chem.278(13),11489-11494(2003)
Su, D., Su, Z., Wang, J., et al.UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in ratsAnat. Rec. (Hoboken)292(6),854-861(2009)
Balakrishnan, M.P., Cilenti, L., Mashak, Z., et al.THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell deathAm. J. Physiol. Heart Circ. Physiol.297(2),H643-H653(2009)
