Necrostatin-5
Cat. No.：YN270742
| 产品名称: | Necrostatin-5 |
| CAS No.: | 337349-54-9 |
| Chemical Name: | 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile |
| Synonyms: | Nec-5 |
| 分子量: | 383.5 |
| 分子式: | C19H17N3O2S2 |
| SMILES: | O=C(C(C(CCCC1)=C1S2)=C2N=C3SCC#N)N3C4=CC=C(OC)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Necrostatin-5 (Nec-5) 是一种有效的细胞坏死 (necroptosis) 抑制剂，EC50值为 0.24 µM。Necrostatin-5 也是一种RIP1抑制剂。Necrostatin-5 具有心脏保护作用。 |
| IC50和靶点: | |
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Degterev, A., Hitomi, J., Germscheid, M., et al.Identification of RIP1 kinase as a specific cellular target of necrostatinsNat. Chem. Biol.4(5),313-321(2008)
González-Juarbe, N., Gilley, R.P., Hinojosa, C.A., et al.Pore-forming toxins induce macrophage necroptosis during acute bacterial pneumoniaPLoS Pathog.11(12),e1005337(2015)
