Fasentin
Cat. No.：YN270749
CAS No. ：392721-37-8
| 产品名称: | Fasentin |
| CAS No.: | 392721-37-8 |
| Chemical Name: | N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-butanamide |
| Synonyms: | |
| 分子量: | 279.6426096 |
| 分子式: | C11H9ClF3NO2 |
| SMILES: | ClC1=C(C(F)(F)F)C=C(NC(CC(C)=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fasentin 是有效的葡萄糖摄取抑制剂，可抑制GLUT-1/GLUT-4转运蛋白。Fasentin 优先抑制GLUT4(IC50=68 μM)。Fasentin 是死亡受体刺激 (FAS) 敏化剂，可敏化细胞对FAS诱导的细胞死亡。Fasentin 也是诱导肿瘤坏死因子 (TNF) 凋亡配体的敏化剂。Fasentin 阻断癌细胞系中的葡萄糖摄取，并具有抗血管生成活性。 |
| IC50和靶点: | [{name:"GLUT4:68 μM (IC50)'}, 'GLUT1'] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wood, T.E., Dalili, S., Simpson, C.D., et al.A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell deathMol. Cancer Ther.7(11),3546-3555(2008)
