IC 86621
Cat. No.：YN270751
| 产品名称: | IC 86621 |
| CAS No.: | 404009-40-1 |
| Chemical Name: | |
| Synonyms: | HMS3229C13; CTK1D4579; IC86621; CHEMBL1317546; DNA-PK Inhibitor III; I2159_SIGMA; 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone; AR2783; SureCN600210; 1-(2-hydroxy-4-morpholin-4-yl-phenyl)-ethanone; |
| 分子量: | 221.25 |
| 分子式: | C12H15NO3 |
| SMILES: | CC(=O)C1=C(O)C=C(C=C1)N2CCOCC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IC 86621 是一种有效的 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂，其IC50为 120 nM。IC 86621 还可作为选择性和可逆的ATP竞争性抑制剂。IC 86621 可抑制DNA-PK介导的细胞 DNA 双链断裂 (DSB) 修复 (EC50=68 µM)。IC 86621 可增加 DSB 诱导的抗肿瘤活性，但没有细胞毒性作用。IC 86621 可防止类风湿关节炎 (RA) T 细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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