Ferutinin
Cat. No.：YN270752
| 产品名称: | Ferutinin |
| CAS No.: | 41743-44-6 |
| Chemical Name: | 4-hydroxy-benzoic acid, (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester |
| Synonyms: | |
| 分子量: | 358.5 |
| 分子式: | C22H30O4 |
| SMILES: | OC1=CC=C(C(O[C@H]2CC(C)=CC[C@]3(C)[C@]2([H])[C@@](C(C)C)(O)CC3)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ferutinin 是一种天然萜类化合物，是一种雌激素受体ERα激动剂和雌激素ERβ受体激动剂/拮抗剂，IC50分别为 33.1 nM 和 180.5 nM。Ferutinin 作为一种产电 Ca2+离子载体，可增加脂质双层膜、线粒体的钙通透性。Ferutinin 具有雌激素、抗肿瘤、抗菌和抗炎活性。 |
| IC50和靶点: | [{name:"ERα:33.1 nM (IC50)"},{name: "ERβ:180.5 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Ikeda, K., Arao, Y., Otsuka, H., et al.Terpenoids found in the Umbelliferae family act as agonists/antagonists for ERα and ERβ: Differential transcription activity between ferutinine-liganded ERα and ERβBiochem. Biophys. Res. Commun.291(2),354-360(2002)
Abramov, A.Y., Zamaraeva, M.V., Hagelgans, A.I., et al.Influence of plant terpenoids on the permeability of mitochondria and lipid bilayersBiochim. Biophys. Acta1512(1),98-110(2001)
Matin, M.M., Nakhaeizadeh, H., Bahrami, A.R., et al.Ferutinin, an apoptosis inducing terpenoid from Ferula ovinaAsian Pac. J. Cancer Prev.15(5),2123-2128(2014)
Zamaraeva, M.V., Charishnikova, O., Saidkhodjaev, A., et al.Calcium mobilization by the plant estrogen ferutinin does not induce blood platelet aggregationPharmacol. Rep.62(6),1117-1126(2010)
