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Colcemid

Cat. No.:YN270756

  • CAS No. :477-30-5

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    • 参考文献
    • 产品名称: Colcemid
      CAS No.: 477-30-5
      Chemical Name: (7S)-6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one
      Synonyms:Demecolcine
      分子量:371.4
      分子式:C21H25NO5
      SMILES:COC1=CC=C2C([C@@H](NC)CCC3=C2C(OC)=C(OC)C(OC)=C3)=CC1=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Colcemid (Demecolcine) 是一种有效的有丝分裂抑制剂,抑制微管蛋白 (tubulin) 聚合的IC50值为 2.4 μM。Colcemid (Demecolcine) 能与微管蛋白二聚体相互作用,诱导抗有丝分裂作用,并抑制微管生长。可用于抗炎和癌症疾病的研究。
      IC50和靶点:
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      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Muzaffar, A., Brossi, A., Lin, C.M., et al.Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoidsJ. Med. Chem.33(2),567-571(1990)

      Rieder, C.L., and Palazzo, R.E.Colcemid and the mitotic cycleJ. Cell Sci.102(3),387-392(1992)

      Jordan, M.A., and Wilson, L.Microtubules as a target for anticancer drugsNat. Rev. Cancer4(4),253-265(2004)

      Curlej, J., Bulla, J., and Chrenek, P.Occurrence of chromosomal aneuploidy in rabbit oocytes and embryos at different developmental stagesZygote18(3),203-207(2010)

      Yang, H., Ganguly, A., and Cabral, F.Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugsJ. Biol. Chem.285(42),32242-32250(2010)

      Bayani, J., and Squire, J.A.Preparation of cytogenetic specimens from tissue samplesCurr. Protoc. Cell Biol.22(22.2),1-15(2004)

      Sablina, A.A., Chumakov, P.M., Levine, A.J., et al.p53 activation in response to microtubule disruption is mediated by integrin-Erk signalingOncogene20(8),899-909(2001)

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