Cytochalasin H
Cat. No.：YN270761
| 产品名称: | Cytochalasin H |
| CAS No.: | 53760-19-3 |
| Chemical Name: | (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-1H-cycloundec[d]isoindol-1-one |
| Synonyms: | |
| 分子量: | 493.6 |
| 分子式: | C30H39NO5 |
| SMILES: | O=C1N[C@@H](CC2=CC=CC=C2)[C@]([C@]31[C@H](OC(C)=O)/C=C/[C@](C)(O)C[C@@H](C)C/C=C/[C@@]3([H])[C@@H]4O)([H])[C@H](C)C4=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytochalasin H 是一种天然产物，可以从真菌Phomopsissp 中分离得到。Cytochalasin H 抑制细胞生长并诱导细胞凋亡 (apoptosis)。Cytochalasin H 具有抗血管生成活性。Cytochalasin H 是一种抗生素，具有抗菌活性。 |
| IC50和靶点: | |
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Brenner, S.L., and Korn, E.D.The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerizationJ. Biol. Chem.255(3),841-844(1980)
Lin, D.C., Tobin, K.D., Grumet, M., et al.Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongationJ. Cell Biol.84(2),455-460(1980)
Ostlund, R.E., Jr., Leung, J.T., and Hajek, S.V.Regulation of microtubule assembly in cultured fibroblastsJ. Cell Biol.85(2),386-391(1980)
Pinder, J.C., and Gratzer, W.B.Structural and dynamic states of actin in the erythrocyteJ. Cell Biol.96(3),768-775(1983)
Flaumenhaft, R., Dilks, J.R., Rozenvayn, N., et al.The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretionBlood105(10),3879-3887(2005)
Taheri-Talesh, N., Horio, T., Araujo-Bazán, L., et al.The tip growth apparatus of Aspergillus nidulansMol. Biol. Cell19(4),1439-1449(2008)
dos Santos, T., Varela, J., Lynch, I., et al.Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell linesPLoS One6(9),1-10(2011)
Nightingale, T.D., White, I.J., Doyle, E.L., et al.Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosisJ. Cell Biol.194(4),613-629(2011)
Walling, E.A., Krafft, G.A., and Ware, B.R.Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recoveryArch. Biochem. Biophys.264(1),321-332(1988)
Yahara, I., Harada, F., Sekita, S., et al.Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitroJ. Cell Biol.92(1),69-78(1982)
Chapla, V.M., Zeraik, M.L., Ximenes, V.F., et al.Bioactive secondary metabolites from Phomopsis sp., and endophytic fungus from Senna spectabilisMolecules19,6597-6608(2014)
Deckert, M., Ticchioni, M., and Bernard, A.Endocytosis of GPI-anchored proteins in human lymphocytes: Role of glycolipid-based domains, actin cytoskeleton, and protein kinasesJ. Cell Biol.133(4),791-799(1996)
Lee, J., Yi, J.M., Kim, H., et al.Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thornsBiol. Pharm. Bull.37(1),6-12(2014)
