LSD1-IN-14
Cat. No.：YN270763
| 产品名称: | LSD1-IN-14 |
| CAS No.: | 54135-60-3 |
| Chemical Name: | 2,2'-methylenebis-1,3-cyclohexanedione |
| Synonyms: | |
| 分子量: | 236.3 |
| 分子式: | C13H16O4 |
| SMILES: | O=C(CCC1)C(CC2C(CCCC2=O)=O)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | M50054 是一种有效的细胞凋亡 (apoptosis) 抑制剂。M50054 抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化，IC50为 79 μg/mL。M50054 不直接抑制 caspase-3 酶活性。M50054可用于研究抗Fas抗体引起的肝炎和化疗引起的脱发。 |
| IC50和靶点: | |
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Tsuda, T., Ohmori, Y., Muramatsu, H., et al.Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-FAS-antibody-induced hepatitis and chemotherapy-induced alopeciaEur. J. Pharmacol.433(1),37-45(2001)
Beane, W.S., Morokuma, J., Lemire, J.M., et al.Bioelectric signaling regulates head and organ size during planarian regenerationDevelop.140,313-322(2013)
Durant, F., Lobo, D., Hammelman, J., et al.Physiological controls of large-scale patterning in planarian regeneration: A molecular and computational perspective on growth and formRegeneration3(2),78-102(2016)
Tseng, A.-S., Adams, D.S., Qiu, D., et al.Apoptosis is required during early stages of tail regeneration in Xenopus laevisDev. Biol.301(1),62-69(2007)
Sirbulescu, R.F., and Zupanc, G.K.Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate systemNeuroscience171(2),599-612(2010)
