Oxamic acid sodium
Cat. No.：YN270765
CAS No. ：565-73-1
| 产品名称: | Oxamic acid sodium |
| CAS No.: | 565-73-1 |
| Chemical Name: | 2-amino-2-oxo-acetic acid, monosodium salt |
| Synonyms: | Sodium oxamate |
| 分子量: | 111 |
| 分子式: | C2H2NO3 • Na |
| SMILES: | [O-]C(C(N)=O)=O.[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oxamic acid (oxamate) sodium salt 是一种LDH-A(乳酸脱氢酶-A) 抑制剂。Oxamic acid sodium salt 表现出抗肿瘤活性，对癌细胞的抗增殖活性，并可诱导细胞凋亡。 |
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Novoa, W.B., Winer, A.D., Glaid, A.J., et al.Lactic dehydrogenase. V. Inhibition by oxamate and by oxalateJ. Biol. Chem.234(5),1143-1148(1959)
Yang, Y., Su, D., Zhao, L., et al.Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cellsOncotarget5(23),11886-11896(2014)
Zub, K.A., de Sousa, M.M.L., Sarno, A., et al.Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cellsPLoS One10(3),e0119857(2015)
Cui, J., Shi, M., Xie, D., et al.FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expressionClin. Cancer Res.20(10),2595-2606(2014)
Zhao, Z., Han, F., Yang, S., et al.Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt-mTOR signaling pathwayCancer Lett.358(1),17-26(2015)
