δ-Secretase inhibitor 11
Cat. No.：YN270779
| 产品名称: | δ-Secretase inhibitor 11 |
| CAS No.: | 842964-18-5 |
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| 分子量: | 220.232 |
| 分子式: | C10H12N4O2 |
| SMILES: | O1CCN(CC1)C2C3C(=NON=3)C(N)=CC=2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | δ-Secretase inhibitor 11 (compound 11) 是一种口服有效、可透过血脑屏障的、无毒、选择性和特异性的δ-secretase抑制剂，其IC50为 0.7 μM。δ-Secretase inhibitor 11 与 δ-Secretase 的活性位点和变构位点相互作用。δ-Secretase inhibitor 11 可衰减 tau 和 APP (淀粉样前体蛋白)的裂解。δ-Secretase inhibitor 11 可改善tau P301S 和 5XFAD 转基因小鼠模型 |
| IC50和靶点: | [{name:"Caspase-3:31.86 ± 1. μM (IC50)"},{name: "Caspase-8:86.71 ± 10 μM (IC50)"}] |
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