Alogliptin
Cat. No.：YN270780
CAS No. ：850649-61-5
| 产品名称: | Alogliptin |
| CAS No.: | 850649-61-5 |
| Chemical Name: | 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile; |
| Synonyms: | 阿格列汀; SYR-322 free base |
| 分子量: | 339.39 |
| 分子式: | C18H21N5O2 |
| SMILES: | CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alogliptin (SYR-322 free base) 是一种有效的、具有选择性口服活性的DPP-4的抑制剂，IC50值小于 10 nM，比对DPP-8和DPP-9的抑制性高 10000 倍以上。Alogliptin 可用于研究 2 型糖尿病。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lynn, F., et al.: Diabetes, 50, 1004 (2001)
Trumper, A., et al.: J. Endocrinol., 174, 233 (2002)
Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)
