Quisinostat dihydrochloride
Cat. No.：YN270786
| 产品名称: | Quisinostat dihydrochloride |
| CAS No.: | 875320-31-3 |
| Chemical Name: | N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide, dihydrochloride |
| Synonyms: | JNJ-26481585 dihydrochloride |
| 分子量: | 467.39166 |
| 分子式: | C21H26N6O2 • 2HCl |
| SMILES: | CN(C1=C2C=CC=C1)C=C2CNCC3CCN(C4=NC=C(C(NO)=O)C=N4)CC3.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) 是一种有口服活性，高效的 pan-HDAC抑制剂，对HDAC1，HDAC2，HDAC4，HDAC10，HDAC11的IC50值分别为 0.11 nM，0.33 nM，0.64 nM，0.46 nM 和 0.37 nM。Quisinostat dihydrochloride 具有广泛的抗肿瘤活性。 |
| IC50和靶点: | [{name:"HDAC1:0.11 nM (IC50)"},{name: "HDAC2:0.33 nM (IC50)"},{name: "HDAC11:0.37 nM (IC50)"},{name: "HDAC10:0.46 nM (IC50)"},{name: "HDAC5:3.69 nM (IC50)"},{name: "HDAC8:4.26 nM (IC50)"},{name: "HDAC3:4.86 nM (IC50)"},{name: "HDAC9:32.1 nM (IC50)"},{name: "HDAC6:76.8 nM (IC50)"},{name: "HDAC7:119 nM (IC50)"}] |
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Arts, J., King, P., Mariën, A., et al.JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activityClin. Cancer. Res15(22),6841-6851(2009)
Wang, X., Liu, K., Gong, H., et al.Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosisToxicol. Appl. Pharmacol.410,115363(2021)
