SCH529074
Cat. No.：YN270789
CAS No. ：922150-11-6
| 产品名称: | SCH529074 |
| CAS No.: | 922150-11-6 |
| Chemical Name: | N3-[2-[[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine |
| Synonyms: | SCH529074 |
| 分子量: | 563.6 |
| 分子式: | C31H36Cl2N6 |
| SMILES: | ClC1=CC=C(C(C2=CC=C(Cl)C=C2)N3CCN(CC4=NC(C=CC=C5)=C5C(NCCCN(C)C)=N4)CC3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SCH529074 是一种具有口服活性的p53激活剂。SCH529074 与 p53 DBD 特异性结合并与构象相关，其Ki值为 1-2 μM。SCH529074 恢复突变的 p53 功能，并阻断 HDM2 介导的野生型 p53 泛素化。SCH529074 可用于非小细胞肺癌 NSCLC 的研究。 |
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Demma, M., Maxwell, E., Ramos, R., et al.SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53J. Biol. Chem.285(14),10198-10212(2010)
