4-MMPB
Cat. No.：YN270791
CAS No. ：928853-86-5
| 产品名称: | 4-MMPB |
| CAS No.: | 928853-86-5 |
| Chemical Name: | 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine |
| Synonyms: | |
| 分子量: | 313.4 |
| 分子式: | C16H19N5S |
| SMILES: | CC1=C(NC(C=CC=C2)=C2S3)C3=NC(N4CCN(C)CC4)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-MMPB 是一种选择性的脂氧合酶15-lipoxygenase抑制剂，其IC50值为 18 μM。4-MMPB 对大豆 15-脂氧合酶 (SLO) 和人 15-脂氧合酶-1 (15-LOX-1) 作用的IC50值分别为 19.5 μM 和 19.1 μM。4-MMPB 具有潜力用于前列腺癌的研究。 |
| IC50和靶点: | |
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Bakavoli, M., Nikpour, M., Rahimizadeh, M., et al.Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitorsBioorg. Med. Chem.15(5),2120-2126(2007)
Nikpour, M., Mousavian, M., Davoodnejad, M., et al.Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanismMed. Chem. Res.22,5036-5043(2013)
