Samuraciclib
Cat. No.：YN270801
| 产品名称: | Samuraciclib |
| CAS No.: | 1805833-75-3 |
| Chemical Name: | |
| Synonyms: | CT7001; ICEC0942 |
| 分子量: | 394.51 |
| 分子式: | C22H30N6O |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Samuraciclib (CT7001) 是一种有效的，具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。Samuraciclib 对CDK7的选择性分别是 CDK1，CDK2(IC50为 578 nM)，CDK5和CDK9的 45 倍，15 倍，230 倍和 30 倍。Samuraciclib 以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有有效的抗肿瘤作用。 |
| IC50和靶点: | [{name:"CDK7/CycH/MAT1:41 nM (IC50)"},{name: "CDK2/cycE1:578 nM (IC50)"},{name: "CDK1:1.8 μM (IC50)"},{name: "CDK4:49 μM (IC50)"},{name: "CDK5:9.4 μM (IC50)"},{name: "CDK6:34 μM (IC50)"},{name: "CDK9:1.2 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
