Droloxifene
Cat. No.：YN480733
CAS No. ：82413-20-5
规格
价格(RMB)
库存
| 产品名称: | Droloxifene |
| CAS No.: | 82413-20-5 |
| Chemical Name: | 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
| Synonyms: | 3-Hydroxytamoxifen |
| 分子量: | 387.51 |
| 分子式: | C₂₆H₂₉NO₂ |
| SMILES: | OC1=CC=CC(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Droloxifene，Tamoxifen 衍生物，是一种具有口服活性和选择性的雌激素受体 (estrogen receptor) 调节剂。Droloxifene 具有抗雌激素和抗植入作用。Droloxifene 诱导 MCF-7 细胞 p53 表达及凋亡。Droloxifene 预防去卵巢大鼠骨丢失。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Robertson, J.F.R.Selective oestrogen receptor modulators/new antioestrogens: A clinical perspectiveCancer Treat. Rev.30(8),695-706(2004)
Löser, R., Seibel, K., Roos, W., et al.In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifenEur. J. Cancer Clin. Oncol.21(8),985-990(1985)
Shen, E.S., Meade, E.H., Pérez, M.C., et al.Expression of functional estrogen receptors and galanin messenger ribonucleic acid in immortalized luteinizing hormone-releasing hormone neurons: Estrogenic control of galanin gene expressionEndocrinology139(3),939-948(1998)
Kawamura, I., Mizota, T., Lacey, E., et al.The estrogenic and antiestrogenic activities of droloxifene in human breast cancersJpn. J. Pharmacol.63(1),27-34(1993)
Greenberger, L.M., Annable, T., Collins, K.I., et al.A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and ratsClin. Cancer Res.7(10),3166-3177(2001)
