Vorinostat
Cat. No.：YN250084
CAS No. ：149647-78-9
| 产品名称: | Vorinostat |
| CAS No.: | 149647-78-9 |
| Chemical Name: | N1-hydroxy-N8-phenyl-octanediamide |
| Synonyms: | 伏立诺他; SAHA; Suberoylanilide hydroxamic acid |
| 分子量: | 264.32 |
| 分子式: | C₁₄H₂₀N₂O₃ |
| SMILES: | O=C(NC1=CC=CC=C1)CCCCCCC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vorinostat (SAHA) 是一种有效的，可口服的HDAC1，HDAC2，HDAC3 (Class I)，HDAC7 (Class II)和Class IV (HDAC11)的抑制剂，对 HDAC1/3 的ID50值分别为 10 nM 和 20 nM。Vorinostat 可以诱导细胞凋亡 (apoptosis)。Vorinostat 还是一种人类乳头瘤病毒 (HPV)-18DNA 扩增的有效抑制剂。 |
| IC50和靶点: | [{name:"HDAC1:10 nM (ID50)"},{name: "HDAC3:20 nM (ID50)'}, 'HDAC2', 'HDAC7', 'HDAC11', 'Autophagy', 'Mitophagy'] |
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| Solvent & Solubility: |
Marks, P.A., and Breslow, R.Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drugNat. Biotechnol.25(1),84-90(2007)
