Galidesivir hydrochloride
Cat. No.：YN250786
| 产品名称: | Galidesivir hydrochloride |
| CAS No.: | 222631-44-9 |
| Chemical Name: | (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol Monohydrochloride; (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol Hydrochloride |
| Synonyms: | BCX 4430 hydrochloride; Immucillin-A hydrochloride |
| 分子量: | 301.73 |
| 分子式: | C₁₁H₁₆ClN₅O₃ |
| SMILES: | O[C@H]1[C@H](C2=CNC3=C2N=CN=C3N)N[C@H](CO)[C@H]1O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Galidesivir (BCX4430) hydrochloride，一种腺苷类似物和直接作用的抗病毒药物，能破坏病毒 RNA 依赖的 RNA 聚合酶(RdRp)活性。Galidesivir hydrochloride 在体外对多种 RNA 病毒病原体具有活性，包括丝状病毒和新兴的感染因子，如 MERS-CoV、SARS-CoV 和 SARS-CoV-2。Galidesivir hydrochloride 对一些负义 RNA 病毒的 EC50在 ~3 到 ~68 μM 之间。 |
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Warren, T., et al.: Nature, 508, 7496 (2014)
Kamat, S., et al.: Biochem., 52, 7366 (2013)
