Embelin
Cat. No.：YN410073
| 产品名称: | Embelin |
| CAS No.: | 550-24-3 |
| Chemical Name: | 2,5-dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | 恩贝酸; Embelic acid; Emberine; NSC 91874 |
| 分子量: | 294.39 |
| 分子式: | C₁₇H₂₆O₄ |
| SMILES: | O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Embelin (Embelic acid) 是一种有效的、非肽类的细胞渗透性XIAP抑制剂 (IC50=4.1 μM)，在高水平 XIAP 的前列腺癌细胞中抑制细胞生长，诱导凋亡 (apoptosis)，并激活 caspase-9。Embelin 阻断 NF-kappaB 信号通路，从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。Embelin 诱导口腔鳞癌细胞自噬和凋亡。 |
| IC50和靶点: | [{name:"XIAP:4.1 μM (IC50)"}] |
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Ahn, K.S., Sethi, G., and Aggarwal, B.B.Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene productsMol. Pharmacol.71(1),209-219(2007)
Hossan, M.S., Fatima, A., Rahmatullah, M., et al.Antiviral activity of Embelia ribes Burm. f. against influenza virus in vitroArch. Virol.163(8),2121-2131(2018)
Nikolovska-Coleska, Z., Xu, L., Hu, Z., et al.Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure databaseJ. Med. Chem.47(10),2430-2440(2004)
Radhakrishnan, N., Gnanamani, A., and Mandal, A.B.A potential antibacterial agent embelin, a natural benzoquinone extracted from Embelia ribesBiol. Med.3(2),1-7(2011)
