Isavuconazonium sulfate
Cat. No.：YN250022
CAS No. ：946075-13-4
| 产品名称: | Isavuconazonium sulfate |
| CAS No.: | 946075-13-4 |
| Chemical Name: | N-methyl-glycine, [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester, monosulfate |
| Synonyms: | BAL8557-002 |
| 分子量: | 814.84 |
| 分子式: | C₃₅H₃₆F₂N₈O₉S₂ |
| SMILES: | O[C@@](CN(N=C1)C=[N+]1C(C)OC(N(C(N=CC=C2)=C2COC(CNC)=O)C)=O)(C(C=C3F)=C(C=C3)F)[C@H](C4=NC(C(C=C5)=CC=C5C#N)=CS4)C.O=[S]([O-])(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Isavuconazonium sulfate (BAL8557-002) 是活性三唑类抗真菌药物 Isavuconazole 的前药，是一种口服活性抗真菌药物。Isavuconazonium sulfate 用于侵袭性曲霉菌病和毛霉菌病。 |
| IC50和靶点: | |
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Seyedmousavi, S., Brüggemann, R.J.M., Meis, J.F., et al.Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection modelAntimicrob. Agents Chemother.59(5),2855-2866(2015)
Petraitis, V., Petraitiene, R., Moradi, P.W., et al.Pharmacokinetics and concentration-dependent efficacy of isavuconazole for treatment of experimental invasive pulmonary aspergillosisAntimicrob. Agents Chemother.60(5),2718-2726(2016)
