Ferrostatin-1
Cat. No.：YN250035
CAS No. ：347174-05-4
| 产品名称: | Ferrostatin-1 |
| CAS No.: | 347174-05-4 |
| Chemical Name: | 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester |
| Synonyms: | Ferrostatin 1,Ferrostatin-1 (Fer-1) |
| 分子量: | 262.35 |
| 分子式: | C₁₅H₂₂N₂O₂ |
| SMILES: | O=C(OCC)C1=CC=C(NC2CCCCC2)C(N)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ferrostatin-1 是一种有效的、选择性的ferroptosis抑制剂，抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 是一种人工合成的抗氧化剂，通过还原机制来防止膜脂的损伤，从而抑制细胞死亡。具有抗真菌活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., et al.Ferroptosis: An iron-dependent form of non-apoptotic cell deathCell149(5),1060-1072(2012)
Skouta, R., Dixon, S.J., Wang, J., et al.Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease modelsJ. Am. Chem. Soc.136(12),4551-4556(2014)
Zilka, O., Shah, R., Li, B., et al.On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell deathACS Cent. Sci.3(3),232-243(2017)
