Prodigiosin
Cat. No.：YN250041
| 产品名称: | Prodigiosin |
| CAS No.: | 82-89-3 |
| Chemical Name: | 4-methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi-1H-pyrrole |
| Synonyms: | 灵菌红素; |
| 分子量: | 323.43 |
| 分子式: | C₂₀H₂₅N₃O |
| SMILES: | CCCCCC1=C/C(N=C1C)=C\C2=C(OC)C=C(C3=CC=CN3)N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prodigiosin (Prodigiosine) 是共生菌的次级代谢物，具有抗真菌和抗肿瘤活性。 |
| IC50和靶点: | |
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Kim, D., Kim, J.F., Yim, J.H., et al.Red to red - the marine bacterium Hahella chejuensis and its product prodigiosin for mitigation of harmful algal bloomsJ. Microbiol. Biotechnol.18(10),1621-1629(2008)
Han, S.B., Park, S.H., Jeon, Y.J., et al.Prodigiosin blocks T cell activation by inhibiting interleukin-2Rα expression and delays progression of autoimmune diabetes and collagen-induced arthritisJ. Pharmacol. Exp. Ther.299(2),415-425(2001)
Soto-Cerrato, V., Viñals, F., Lambert, J.R., et al.Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3β activity in human breast cancer cellsMol. Cancer Ther.6(1),362-369(2016)
Hong, B., Prabhu, V.V., Zhang, S., et al.Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53Cancer Res.74(4),1153-1165(2014)
Hosseini, A., Espona-Fiedler, M., Soto-Cerrato, V., et al.Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family membersPLoS One8(2),(2013)
Woo, J.T., Yonezawa, T., Cha, B.Y., et al.Pharmacological topics of bone metabolism: Antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survivalJ. Pharmacol. Sci.106(4),547-554(2008)
