Damnacanthal
Cat. No.：YN250165
| 产品名称: | Damnacanthal |
| CAS No.: | 477-84-9 |
| Chemical Name: | 9,10-Dihydro-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde; 9,10-Dihydro-3-hydroxy-1-methoxy-9,10-dioxo-2-anthraldehyde; 3-Hydroxy-1-methoxy-2-anthraquinonecarboxaldehyde; |
| Synonyms: | 丹宁卡 |
| 分子量: | 282.25 |
| 分子式: | C₁₆H₁₀O₅ |
| SMILES: | O=CC(C(OC)=C1C2=O)=C(O)C=C1C(C3=C2C=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Damnacanthal 是从Morinda citrifolia的根中分离出来的蒽醌。Damnacanthal 是一种强效选择性的p56lck酪氨酸激酶活性的抑制剂。天然的 Damnacanthal 抑制p56lck的自磷酸化和外源底物的磷酸化，IC50分别为 46 nM 和 220 nM。Damnacanthal 是一种具有抗癌活性的有效凋亡诱导剂。Damnacanthal 在小鼠中也具有镇痛，抗炎作用，并且对白色念珠菌具有抗真菌活性。 |
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| Solvent & Solubility: |
Hiramatsu, et al.: Cancer Lett., 73, 161 (1993), Faltynek, et al.: Biochemistry, 34, 12404 (1995), Aoki, et al.: Eur. J. Pharmacol., 387, 119 (2000),
