Alexidine dihydrochloride
Cat. No.：YN250168
CAS No. ：1715-30-6
| 产品名称: | Alexidine dihydrochloride |
| CAS No.: | 1715-30-6 |
| Chemical Name: | N1,N14-bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, dihydrochloride |
| Synonyms: | 2,4,11,13-Tetraazatetradecanediimidamide,N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride (1:2);2,4,11,13-Tetraazatetradecanediimidamide,N1,N14-bis(2-ethylhexyl)-3,12-diimino-, hydrochloride...;Alexidine (hydrochloride);Alexidine dihydrochloride;Alex |
| 分子量: | 581.71 |
| 分子式: | C₂₆H₅₈Cl₂N₁₀ |
| SMILES: | N=C(NCC(CC)CCCC)NC(NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N)=N.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alexidine dihydrochloride 是一种抗癌剂，靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶PTPMT1，并导致线粒体凋亡。Alexidine dihydrochloride 具有对多种真菌病原体的抗真菌和抗生物膜活性。 |
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Zorko, M., and Jerala, R.Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibioticsJ. Antimicrob. Chemother.62(4),730-737(2008)
Ganendren, R., Widmer, F., Singhal, V., et al.In vitro antifungal activities of inhibitors of phospholipases from the fungal pathogen Cryptococcus neoformansAntimicrob. Agents Chemother.48(5),1561-1569(2004)
Doughty-Shenton, D., Joseph, J.D., Zhang, J., et al.Pharmacological targeting of the mitochondrial phosphatase PTPMT1J. Pharmacol. Exp. Ther.333(2),584-592(2010)
Yip, K.W., Ito, E., Mao, X., et al.Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agentMol. Cancer Ther.5(9),2234-2240(2006)
