Caerulomycin A
Cat. No.：YN250237
| 产品名称: | Caerulomycin A |
| CAS No.: | 21802-37-9 |
| Chemical Name: | (E)-4-methoxy-[2,2'-bipyridine]-6-carboxaldehyde oxime |
| Synonyms: | Cerulomycin; Caerulomycin |
| 分子量: | 229.23 |
| 分子式: | C₁₂H₁₁N₃O₂ |
| SMILES: | COC1=CC(C2=NC=CC=C2)=NC(/C=N/O)=C1.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Caerulomycin A (Cerulomycin; Caerulomycin) 是一种抗真菌 (antifungal) 化合物，能够诱导 T 细胞的产生。Caerulomycin A 能够抑制 IFN-γ 诱导的 STAT1 通路，从而增强 TGF-β-Smad3 信号通路。具有抗真菌和抗细菌活性，可用于自身免疫病的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ambavane, V., Tokdar, P., Parab, R., et al.Caerulomycin A - An antifungal compound isolated from marine actinomycetesAdv. Microbiol.4(9),567-578(2014)
Gurram, R.K., Kujur, W., Maurya, S.K., et al.Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs)J. Biol. Chem.289(25),17515-17528(2014)
Kujur, W., Gurram, R.K., Haleem, N., et al.Caerulomycin A inhibits Th2 cell activity: A possible role in the management of asthmaSci. Rep.5,15396(2015)
Kujur, W., Gurram, R.K., Maurya, S.K., et al.Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitisAutoimmunity50(5),317-328(2017)
