Reveromycin A
Cat. No.：YN250429
| 产品名称: | Reveromycin A |
| CAS No.: | 134615-37-5 |
| Chemical Name: | butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester |
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| 分子量: | 660.79 |
| 分子式: | C₃₆H₅₂O₁₁ |
| SMILES: | O=C(O[C@@]1(CCCC)[C@H](/C=C/C(C)=C/C(O)=O)O[C@]2(O[C@H](C/C=C(C)/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)[C@@H](C)CC2)CC1)CCC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Reveromycin A 是一种从链霉菌属中分离出来的苯甲醌类抗生素 (antibiotic)，是选择性的真核细胞中蛋白质合成 (protein synthesis) 抑制剂。Reveromycin A 通过诱导破骨细胞的凋亡 (apoptosis) 来抑制骨吸收。Reveromycin A 对肿瘤细胞系具有抗增殖活性，并具有抗真菌 (antifungal) 活性。 |
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Takahashi, H., Osada, H., Koshino, H., et al.Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activitiesJ. Antibiot. (Tokyo)45(9),1414-1419(1992)
Woo, J.T., Kawatani, M., Kato, M., et al.Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclastsProc. Natl. Acad. Sci. USA103(12),4729-4734(2006)
