Hygrolidin
Cat. No.：YN250472
| 产品名称: | Hygrolidin |
| CAS No.: | 83329-73-1 |
| Chemical Name: | 2E-butenedioic acid, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4 |
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| 分子量: | 690.86 |
| 分子式: | C₃₈H₅₈O₁₁ |
| SMILES: | O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\C)OC2=O)C)(O)O[C@H](CC)[C@@H]1C)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hygrolidin 是一种 16 元大环内酯类抗生素，来自于吸水链霉菌 (Streptomyces hygroscopicus) D-1166。Hygrolidin 对Valsa ceratosperma具有抗真菌活性。Hygrolidin 诱导 p21 表达并中止 G1 和 S 期的细胞周期进程。Hygrolidin 具有抗肿瘤活性。 |
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Seto, H., Akao, H., Furihata, K., et al.The structure of a new antibiotic, hygrolidinTetrahedron Lett.23(26),2667-2670(1982)
Kawada, M., Usami, I., Ohba, S., et al.Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phasesBiochem. Biophys. Res. Commun.298(1),178-183(2002)
Annang, F., Pérez-Moreno, G., García-Hernández, R., et al.High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: Human African trypanosomiasis, leishmaniasis, and Chagas diseaseJ. Biomol. Screen.20(1),82-91(2015)
