Pseudolaric Acid B
Cat. No.：YN251731
CAS No. ：82508-31-4
| 产品名称: | Pseudolaric Acid B |
| CAS No.: | 82508-31-4 |
| Chemical Name: | (3R,4S,4aS,9aR)-4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylic acid, 7-methyl ester |
| Synonyms: | 土荆皮乙酸 |
| 分子量: | 432.46 |
| 分子式: | C₂₃H₂₈O₈ |
| SMILES: | O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@@](C)(/C=C/C=C(C(O)=O)\C)O3)(CC2)C3=O)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pseudolaric Acid B 是一种从Pseudolarix kaempferiGorden (pinaceae) 根部分离的二萜酸，具有抗癌、抗真菌、抗受精活性，并对 T 淋巴细胞也具有免疫抑制活性。Pseudolaric Acid B 通过凋亡和细胞周期阻滞抑制乙肝病毒(HBV)的分泌。Pseudolaric Acid B 诱导细胞自噬。 |
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Li, E., Clark, A.M., and Hufford, C.D.Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferiJ. Nat. Prod.58(1),57-67(1995)
Gong, X., Wang, M., Tashiro, S.i., et al.Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell deathExp. Mol. Med.38(4),428-434(2006)
Wong, V.K.W., Chiu, P., Chung, S.S.M., et al.Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivoClin. Cancer Res.11(16),6002-6011(2005)
Li, M.H., Miao, Z.H., Tan, W.F., et al.Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradationClin. Cancer Res.10(24),8266-8274(2004)
