Jasplakinolide
Cat. No.：YN251798
CAS No. ：102396-24-7
| 产品名称: | Jasplakinolide |
| CAS No.: | 102396-24-7 |
| Chemical Name: | cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-8S-hydroxy-2S,4E,6R-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl] |
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| 分子量: | 709.67 |
| 分子式: | C₃₆H₄₅BrN₄O₆ |
| SMILES: | BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，Kd值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽，具有抗真菌和抗肿瘤活性。 |
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Bubb, M.R., Senderowicz, A.M.J., Sausville, E.A., et al.Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actinJ. Biol. Chem.269(21),14869-14871(1994)
Bubb, M.R., Spector, I., Beyer, B.B., et al.Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observationsJ. Biol. Chem.275(7),5163-5170(2000)
Van Goor, D., Hyland, C., Schaefer, A.W., et al.The role of actin turnover in retrograde actin network flow in neuronal growth conesPLoS One7(2),(2012)
Zhang, X., Cui, X., Cheng, L., et al.Actin stabilization by jasplakinolide affects the function of bone marrow-derived late endothelial progenitor cellsPLoS One7(11),(2012)
