U93631
Cat. No.：YN360043
CAS No. ：152273-12-6
| 产品名称: | U93631 |
| CAS No.: | 152273-12-6 |
| Chemical Name: | 4,5-dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid, 1,1-dimethylethyl ester |
| Synonyms: | U-93631; U 93631 |
| 分子量: | 299.37 |
| 分子式: | C₁₇H₂₁N₃O₂ |
| SMILES: | O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | U93631是一种高效的GABAA受体的配体，其IC50为100 nM，由GABA通过重组GABAA受体诱导产生全细胞Cl流，这种效果会被U93961迅速抑制，并且这种抑制作用是随着时间衰减的。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Dillon, G.H., Im, H.K., Hamilton, B.J., et al.U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptorsMol. Pharmacol.44(4),860-865(1993)
Dillon, G.H., Im, W.B., Pregenzer, J.F., et al.[4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probabilityJ. Pharmacol. Exp. Ther.272(2),597-603(1995)
