Guvacine hydrochloride
Cat. No.：YN360054
| 产品名称: | Guvacine hydrochloride |
| CAS No.: | 6027-91-4 |
| Chemical Name: | 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, monohydrochloride |
| Synonyms: | |
| 分子量: | 163.60 |
| 分子式: | C₆H₁₀ClNO₂ |
| SMILES: | O=C(C1=CCCNC1)O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Guvacine hydrochloride 是从槟榔中得到的生物碱，为GABA transporter的抑制剂，对几种克隆的 GABA 转运体具有适度的选择性，IC50值分别为 14 μM (human GAT-1)，39 μM (rat GAT-1)，58 μM (rat GAT-2)，119 μM (human GAT-3)，378 μM (rat GAT-3) 和 1870 μM (human BGT-3)。 |
| IC50和靶点: | |
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Johnston, G.A., Krogsgaard-Larsen, P., and Stephanson, A.Betel nut constituents as inhibitors of γ-aminobutyric acid uptakeNature258(5536),627-628(1975)
Pavia, M.R., Lobbestael, S.J., Nugiel, D., et al.Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptakeJ. Med. Chem.35(22),4238-4248(1992)
Mantegazza, P., Tammiso, R., Vicentini, L., et al.Nipecotic acid and guvacine antagonism on morphine analgesia in ratsPharmacol. Res. Commun.11(8),657-662(1979)
