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Isoguvacine hydrochloride

Cat. No.:YN360055

  • CAS No. :68547-97-7

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    • 产品名称: Isoguvacine hydrochloride
      CAS No.: 68547-97-7
      Chemical Name: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid, monohydrochloride
      Synonyms:异四氢烟酸
      分子量:163.60
      分子式:C₆H₁₀ClNO₂
      SMILES:O=C(C1=CCNCC1)O.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Isoguvacine hydrochloride是GABA受体激动剂。
      IC50和靶点:
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      In Vivo:
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      Solvent & Solubility:
    • Petersen, J.G., Sørensen, T., Damgaard, M., et al.Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonistsEur. J. Med. Chem.84,404-416(2014)

      Kemp, J.A., Marshall, G.R., and Woodruff, G.N.Quantitative evaluation of the potencies of GABA-receptor agonists and antagonists using the rat hippocampal slice preparationBr. J. Pharmacol.87(4),677-684(1986)

      Isaev, D., Isaeva, E., Khazipov, R., et al.Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitroJ. Neurophysiol.94(4),2987-2992(2005)

      Orefice, L.L., Mosko, J.R., Morency, D.T., et al.Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD modelsCell178(4),867-886(2019)

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