FG 7142
Cat. No.：YN360063
| 产品名称: | FG 7142 |
| CAS No.: | 78538-74-6 |
| Chemical Name: | N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide |
| Synonyms: | ZK 39106; LSU-65 |
| 分子量: | 225.25 |
| 分子式: | C₁₃H₁₁N₃O |
| SMILES: | O=C(C1=CC2=C(C=N1)NC3=C2C=CC=C3)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FG 7142 (ZK 39106; LSU-65) 是一种非选择性的苯二氮杂卓反向激动剂，对含 α1 亚基的GABAA receptor具有高亲和力 (Ki= 91 nM)。FG 7142 (ZK 39106; LSU-65) 还调节表达 α1 亚基的 GABAA 受体上 GABA 诱导的氯通量 (EC50= 137 nM)。FG 7142 (ZK 39106; LSU-65) 可以增加酪氨酸羟化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。 |
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Miller, L.G., Heller, J., Lumpkin, M., et al.Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neuronsBiochem. Pharmacol.40(6),1337-1344(1990)
Beck, C.H., and Cooper, S.J.β-Carboline FG 7142-reduced aggression in male rats: Reversed by the benzodiazepine receptor antagonist, Ro15-1788Pharmacol. Biochem. Behav.24(6),1645-1649(1986)
Little, H.J., Nutt, D.J., and Taylor, S.C.Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: Proconvulsant properties and kindlingBr. J. Pharmacol.83(4),951-958(1984)
Cottone, P., Sabino, V., Steardo, L., et al.FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: Evidence that benzodiazepine inverse agonists reduce food palatabilityNeuropsychopharmacology32(5),1069-1081(2007)
