WZB117
Cat. No.：YN360676
CAS No. ：1223397-11-2
| 产品名称: | WZB117 |
| CAS No.: | 1223397-11-2 |
| Chemical Name: | 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester |
| Synonyms: | WZB117,WZB-117,WZB 117 |
| 分子量: | 368.31 |
| 分子式: | C₂₀H₁₃FO₆ |
| SMILES: | OC1=CC=CC(C(OC2=CC=CC(F)=C2OC(C3=CC(O)=CC=C3)=O)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WZB117 是一种葡萄糖转运蛋白 1 (Glut1) 抑制剂，可下调糖酵解，诱导细胞周期停滞，并在体内外抑制癌细胞生长。 |
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Liu, Y., Cao, Y., Zhang, W., et al.A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivoMol. Cancer Ther.11(8),1672-1682(2012)
Xintaropoulou, C., Ward, C., Wise, A., et al.A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line modelsOncotarget6(28),25677-25695(2015)
Shibuya, K., Okada, M., Suzuki, S., et al.Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cellsOncotarget6(2),651-661(2015)
