Phloretin
Cat. No.：YN360909
| 产品名称: | Phloretin |
| CAS No.: | 60-82-2 |
| Chemical Name: | 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone |
| Synonyms: | 根皮素; NSC 407292; RJC 02792 |
| 分子量: | 274.27 |
| 分子式: | C₁₅H₁₄O₅ |
| SMILES: | O=C(C1=C(O)C=C(O)C=C1O)CCC2=CC=C(O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phloretin (NSC 407292; RJC 02792) 是一种从夏枯草中提取的黄酮类化合物，具有抗炎活性。Phloridzin 是一种特异性、竞争性和口服活性的钠/葡萄糖协同转运蛋白 (sodium/glucose cotransporters) 抑制剂，在肠道 (SGLT1) 和肾脏 (SGLT2)。Phloretin 抑制 Yeast-made GLUT1 以及人类红细胞 GLUT1 的IC50值分别为 49 μM 和 61 μM。Phloretin 具有潜力用于类风湿性关节炎 (RA) |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bröer, S., Bröer, A., Schneider, H.P., et al.Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytesBiochem. J.341(Pt 3),529-535(1999)
Wielert-Badt, S., Lin, J.T., Lorenz, M., et al.Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysisJ. Med. Chem.43(9),1692-1698(2000)
Gupte, A., and Buolamwini, J.K.Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitorsBioorg. Med. Chem. Lett.19(3),917-921(2009)
