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Goserelin acetate

Cat. No.:YN320785

  • CAS No. :145781-92-6

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    • 产品名称: Goserelin acetate
      CAS No.: 145781-92-6
      Chemical Name: 2-(aminocarbonyl)hydrazide-6-[O-(1,1-dimethylethyl)-D-serine]-1-9-luteinizing hormone-releasing factor (swine), acetate
      Synonyms:醋酸戈舍瑞林; ICI-118630 acetate
      分子量:1329.46
      分子式:C₆₁H₈₈N₁₈O₁₆
      SMILES:O=C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](COC(C)(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(NNC(N)=O)=O)=O)=O)=O)=O)=O)CO)[C@@H](NC([C@H](CC3=CN=CN3)NC([C@@H](N4)CCC4=O)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Goserelin acetate (ICI-118630 acetate) 是一种促性腺激素释放激素 (GnRH) 类似物,能作为GnRH激动剂。Goserelin acetate 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。
      IC50和靶点:
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    • Nederpelt, I., Georgi, V., Schiele, F., et al.Characterization of 12 GnRH peptide agonists - a kinetic perspectiveBr. J. Pharmacol.173(1),128-141(2016)

      Chatzaki, E., Bax, C.M., Eidne, K.A., et al.The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factorCancer Res.56(9),2059-2065(1996)

      Sullivan, M.H., and Cooke, B.A.The role of calcium in luteinizing hormone-releasing hormone agonist (ICI 118630)-stimulated steroidogenesis in rat Leydig cellsBiochem. J.218(2),621-624(1984)

      Ward, J.A., Furr, B.J., Valcaccia, B., et al.Prolonged suppression of rat testis function by a depot formulation of Zoladex, a GnRH agonistJ. Androl.10(6),478-486(1989)

      Dondi, D., Moretti, R.M., Montagnani, M.M., et al.Growth-inhibitory effects of luteinizing hormone-releasing hormone (LHRH) agonists on xenografts of the DU 145 human androgen-independent prostate cancer cell line in nude miceInt. J. Cancer76(4),506-511(1998)

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