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SB-332235

Cat. No.:YN322446

  • CAS No. :276702-15-9

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    • 产品名称: SB-332235
      CAS No.: 276702-15-9
      Chemical Name: 6-chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxy-benzenesulfonamide
      Synonyms:SB332235;SB-332235
      分子量:410.66042
      分子式:C13H10Cl3N3O4S
      SMILES:O=C(NC1=CC=C(C(S(N)(=O)=O)=C1O)Cl)NC2=C(Cl)C(Cl)=CC=C2
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: SB-332235 是一种高效、口服活性、选择性的非肽CXCR2拮抗剂,IC50为 7.7 nM。SB-332235 对CXCR2的选择性比CXCR1高 285 倍。SB-332235 对家兔急性和慢性关节炎模型的抑制作用。SB-332235 抑制 AML 细胞活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Podolin, P.L., Bolognese, B.J., Foley, J.J., et al.A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbitJ. Immunol.169(11),6435-6444(2002)

      Traves, S.L., Smith, S.J., Barnes, P.J., et al.Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: A role for CXCR2J. Leukoc. Biol.76(2),441-450(2004)

      Stevenson, C.S., Coote, K., Webster, R., et al.Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effectAm. J. Physiol. Lung Cell. Mol. Physiol.288(3),L514-L522(2005)

      Ryu, J.K., Cho, T., Choi, H.B., et al.Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer's diseaseJ. Neuroinflammation12,144(2015)

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