BAR501
Cat. No.：YN320123
CAS No. ：1632118-69-4
| 产品名称: | BAR501 |
| CAS No.: | 1632118-69-4 |
| Chemical Name: | (3α,5β,6β,7β)-6-ethyl-cholane-3,7,24-triol |
| Synonyms: | BAR 501 |
| 分子量: | 406.64 |
| 分子式: | C₂₆H₄₆O₃ |
| SMILES: | C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAR501是高效选择性的GPBAR1激动剂，EC50值为1 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Renga, B., Cipriani, C., Carino, A., et al.Reversal of endothelial dysfunction by GPBAR1 agonism in portal hypertension involves a AKT/FOXOA1 dependent regulation of H2S generation and Endothelin-1.PLoS One5;10(11),(2015)
Biagioli, M., Carino, A., Cipriani, S., et al.The bile acid receptor GPBAR1 regulates the M1/M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis.J. Immunol.199(2),718-733(2017)
