Hyodeoxycholic acid
Cat. No.：YN321714
| 产品名称: | Hyodeoxycholic acid |
| CAS No.: | 83-49-8 |
| Chemical Name: | (3α,5β,6α)-3,6-dihydroxy-cholan-24-oic acid |
| Synonyms: | 猪去氧胆酸; HDCA |
| 分子量: | 392.57 |
| 分子式: | C₂₄H₄₀O₄ |
| SMILES: | C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为TGR5 (GPCR19)的激动剂，在 CHO 细胞中，EC50值为 31.6 µM。 |
| IC50和靶点: | |
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Einarsson, K.On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154J. Biol. Chem.241(3),534-539(1966)
Madsen, D., Beaver, M., Chang, L., et al.Analysis of bile acids in conventional and germfree ratsJ. Lipid. Res.17(2),107-111(1976)
Sacquet, E., Parquet, M., Riottot, M., et al.Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in manJ. Lipid. Res.24(5),604-613(1983)
Shih, D.M., Shaposhnik, Z., Meng, Y., et al.Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout miceFASEB J.27(9),3805-3817(2013)
Gnewuch, C., Liebisch, G., Langmann, T., et al.Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel diseaseWorld J. Gastroenterol.15(25),3134-3141(2009)
