Deoxycholic acid
Cat. No.：YN321725
| 产品名称: | Deoxycholic acid |
| CAS No.: | 83-44-3 |
| Chemical Name: | (3α,5β,12α)-3,12-dihydroxy-cholan-24-oic acid |
| Synonyms: | 去氧胆酸; Cholanoic Acid; Desoxycholic acid |
| 分子量: | 392.57 |
| 分子式: | C₂₄H₄₀O₄ |
| SMILES: | C[C@@]1([C@@]2([H])[C@H](C)CCC(O)=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Deoxycholic acid 激活 G 蛋白偶联胆汁酸受体TGR5。 |
| IC50和靶点: | |
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Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe45,86-100(2017)
Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2),e0148869(2016)
Šarenac, T.M., and Mikov, M.Bile acid synthesis: From nature to the chemical modification and synthesis and their applications as drugs and nutrientsFront. Pharmacol.9,939(2018)
Qiao, D., Gaitonde, S.V., Qi, W., et al.Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradationCarcinogenesis22(6),957-964(2001)
Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13),3624-3632(2019)
Bayerdörffer, E., Mannes, G.A., Richter, W.O., et al.Increased serum deoxycholic acid levels in men with colorectal adenomasGastroenterology104(1),145-151(1993)
