Monomethyl fumarate
Cat. No.：YN320251
| 产品名称: | Monomethyl fumarate |
| CAS No.: | 2756-87-8 |
| Chemical Name: | 2E-butenedioic acid, 1-methyl ester |
| Synonyms: | 富马酸单甲酯 |
| 分子量: | 130.10 |
| 分子式: | C₅H₆O₄ |
| SMILES: | O=C(OC)/C=C/C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Monomethyl fumarate 是 Dimethyl fumarate (DMF) 的活性代谢产物，一种有效的 GPR109A 激动剂。Monomethyl fumarate 具有用于多种神经保护途径和其他视网膜疾病模型的潜力。 |
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Dibbert, S., Clement, B., Skak-Nielsen, T., et al.Detection of fumarate-glutathione adducts in the portal vein blood of rats: Evidence for rapid dimethylfumarate metabolismArch. Dermatol. Res.305(5),447-451(2013)
Tang, H., Lu, J.Y.-L., Zheng, X., et al.The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonistBiochem. Biophys. Res. Commun.375(4),562-565(20008)
Chen, H., Assmann, J.C., Krenz, A., et al.Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAEJ. Clin. Invest.124(5),2188-2192(2014)
Helwa, I., Patel, R., Karempelis, P., et al.The antipsoriatic agent monomethylfumarate has antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytesJ. Pharmacol. Exp. Ther.352(1),90-97(2015)
Al-Jaderi, Z., and Maghazachi, A.A.Vitamin D₃ and monomethyl fumarate enhance natural killer cell lysis of dendritic cells and ameliorate the clinical score in mice suffering from experimental autoimmune encephalomyelitisToxins (Basel)7(11),4730-4744(2015)
